Publications

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A J Miller, B R Dye, D Ferrer-Torres, D R Hill, A W Overeem, L D Shea, J R Spence. Generation of lung organoids from human pluripotent stem cells in vitro.. In: Nat Protoc, https://doi.org/10.1038/s41596-018-0104-8, 2019.

A J Miller, D R Hill, M S Nagy, Y Aoki, B R Dye, A M Chin, S Huang, F Zhu, E S White, V Lama, J R Spence. In Vitro Induction and In Vivo Engraftment of Lung Bud Tip Progenitor Cells Derived from Human Pluripotent Stem Cells.. In: Stem Cell Reports, (10), 1, pp. 101-119, https://doi.org/10.1016/j.stemcr.2017.11.012, 2018.

M K Dame, D Attili, S D McClintock, P H Dedhia, P Ouillette, O Hardt, A M Chin, X Xue, J Laliberte, E L Katz, G M Newsome, D R Hill, A J Miller, Y H Tsai, D Agorku, C H Altheim, A Bosio, B Simon, L C Samuelson, J A Stoerker, H D Appelman, J Varani, M S Wicha, D E Brenner, Y M Shah, J R Spence, J A Colacino. Identification, isolation and characterization of human LGR5-positive colon adenoma cells.. In: Development, (145), 6, https://doi.org/10.1242/dev.153049, 2018.

David R. Hill, Sha Huang, Yu-Hwai Tsai, Jason R. Spence, Vincent B. Young. Real-time Measurement of Epithelial Barrier Permeability in Human Intestinal Organoids. JoVE, 2017.

PDF Code Project Project Video DOI

David R Hill, Jason R Spence. Gastrointestinal Organoids: Understanding the Molecular Basis of the Host–Microbe Interface. CMGH, 2017.

David R Hill, Sha Huang, Melinda S Nagy, Veda K Yadagiri, Courtney Fields, Dishari Mukherjee, Brooke Bons, Priya H Dedhia, Alana M Chin, Yu-Hwai Tsai, Shrikar Thodla, Thomas M Schmidt, Seth Walk, Vincent B Young, Jason R Spence. Bacterial colonization stimulates a complex physiological response in the immature human intestinal epithelium. eLife, 2017.

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D R Hill, S Huang, Y H Tsai, J R Spence, V B Young. Real-time Measurement of Epithelial Barrier Permeability in Human Intestinal Organoids.. In: J Vis Exp, 130, https://doi.org/10.3791/56960, 2017.

A M Chin, D R Hill, M Aurora, J R Spence. Morphogenesis and maturation of the embryonic and postnatal intestine.. In: Semin Cell Dev Biol, (66), pp. 81-93, https://doi.org/10.1016/j.semcdb.2017.01.011, 2017.

D R Hill, J R Spence. Gastrointestinal Organoids: Understanding the Molecular Basis of the Host-Microbe Interface.. In: Cell Mol Gastroenterol Hepatol, (3), 2, pp. 138-149, https://doi.org/10.1016/j.jcmgh.2016.11.007, 2017.

D R Hill, S Huang, M S Nagy, V K Yadagiri, C Fields, D Mukherjee, B Bons, P H Dedhia, A M Chin, Y H Tsai, S Thodla, T M Schmidt, S Walk, V B Young, J R Spence. Bacterial colonization stimulates a complex physiological response in the immature human intestinal epithelium.. In: Elife, (6), https://doi.org/10.7554/eLife.29132, 2017.

Y He, S Liu, D E Kling, S Leone, N T Lawlor, Y Huang, S B Feinberg, D R Hill, D S Newburg. The human milk oligosaccharide 2'-fucosyllactose modulates CD14 expression in human enterocytes, thereby attenuating LPS-induced inflammation.. In: Gut, (65), 1, pp. 33-46, https://doi.org/10.1136/gutjnl-2014-307544, 2016.

Yu-Hwai Tsai, David R. Hill, Namit Kumar, Sha Huang, Alana M. Chin, Briana R. Dye, Melinda S. Nagy, Michael P. Verzi, Jason R. Spence. LGR4 and LGR5 Function Redundantly During Human Endoderm Differentiation. In: Cellular and Molecular Gastroenterology and Hepatology, (2), 5, pp. 648 - 662.e8, https://doi.org/https://doi.org/10.1016/j.jcmgh.2016.06.002, http://www.sciencedirect.com/science/article/pii/S2352345X16300728, 2016.

S R Finkbeiner, D R Hill, C H Altheim, P H Dedhia, M J Taylor, Y H Tsai, A M Chin, M M Mahe, C L Watson, J J Freeman, R Nattiv, M Thomson, O D Klein, N F Shroyer, M A Helmrath, D H Teitelbaum, P J Dempsey, J R Spence. Transcriptome-wide Analysis Reveals Hallmarks of Human Intestine Development and Maturation In Vitro and In Vivo.. In: Stem Cell Reports, https://doi.org/10.1016/j.stemcr.2015.04.010, 2015.

S Albeiroti, K Ayasoufi, D R Hill, B Shen, C A {de la Motte}. Platelet hyaluronidase-2: an enzyme that translocates to the surface upon activation to function in extracellular matrix degradation.. In: Blood, (125), 9, pp. 1460-9, https://doi.org/10.1182/blood-2014-07-590513, 2015.

A M Vickers, S Starks-Solis, D R Hill, D S Newburg. Pasteurized Donor Human Milk Maintains Microbiological Purity for 4 Days at 4°C.. In: J Hum Lact, (31), 3, pp. 401-5, https://doi.org/10.1177/0890334415576512, 2015.

B R Dye, D R Hill, M A Ferguson, Y H Tsai, M S Nagy, R Dyal, J M Wells, C N Mayhew, R Nattiv, O D Klein, E S White, G H Deutsch, J R Spence. In vitro generation of human pluripotent stem cell derived lung organoids.. In: Elife, (4), https://doi.org/10.7554/eLife.05098, 2015.

D R Hill, D S Newburg. Clinical applications of bioactive milk components.. In: Nutr Rev, (73), 7, pp. 463-76, https://doi.org/10.1093/nutrit/nuv009, 2015.

D R Hill, H K Rho, S P Kessler, R Amin, C R Homer, C McDonald, M K Cowman, C A {de la Motte}. Human milk hyaluronan enhances innate defense of the intestinal epithelium.. In: J Biol Chem, (288), 40, pp. 29090-104, https://doi.org/10.1074/jbc.M113.468629, 2013.

D R Hill, S P Kessler, H K Rho, M K Cowman, C A {de la Motte}. Specific-sized hyaluronan fragments promote expression of human β-defensin 2 in intestinal epithelium.. In: J Biol Chem, (287), 36, pp. 30610-24, https://doi.org/10.1074/jbc.M112.356238, 2012.

S K Bandyopadhyay, C A {de la Motte}, S P Kessler, V C Hascall, D R Hill, S A Strong. Hyaluronan-mediated leukocyte adhesion and dextran sulfate sodium-induced colitis are attenuated in the absence of signal transducer and activator of transcription 1.. In: Am J Pathol, (173), 5, pp. 1361-8, https://doi.org/10.2353/ajpath.2008.080444, 2008.